Drug interactions

Dipipanone + Ketamine

Severity: Major

Dipipanone and Ketamine: major interaction.

Last updated 29 Oct 2026 Sources: US FDA label

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Dipipanone is a strong opioid analgesic, and combining it with ketamine raises the risk of excessive sedation and respiratory depression.

Ketamine

What this interaction means in plain words

Dipipanone and Ketamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Evidence level: Moderate

Why it happens

Additive CNS and respiratory depression via opioid receptor agonism and NMDA antagonism.

What to do

Reduce initial doses and monitor respiratory rate, oxygen saturation and sedation. Keep naloxone available.

What to ask your pharmacist

Does the benefit of taking both outweigh the risk in my case?
Do I need any blood test, ECG or other check while on both?
What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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References

Ketalar - FDA drug label (DailyMed) - section 7 Drug Interactions (class statement: opioid analgesics; "Concomitant use of ketamine with opioid analgesics, benzodiazepines, or other central nervous system (CNS) depressants, including alcohol, may result in profoun") — DailyMed (FDA label)

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Frequently asked questions

Can I take Dipipanone with Ketamine?

MediHelp rates the interaction as major. Dipipanone and Ketamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dipipanone is a strong opioid analgesic, and combining it with ketamine raises the risk of excessive sedation and respiratory depression.

How serious is the interaction between Dipipanone and Ketamine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce initial doses and monitor respiratory rate, oxygen saturation and sedation. Keep naloxone available.

What other medicines interact with Ketamine?

MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.

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