Drug interactions
Dipipanone + Pimozide
Severity: Moderate
Dipipanone and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipipanone is an opioid analgesic that, with pimozide, can cause additive sedation, hypotension and respiratory depression.
What this interaction means in plain words
Dipipanone and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression.
What to do
Start with a low opioid dose and monitor sedation and respiratory rate. Avoid alcohol and other CNS depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Dipipanone with Pimozide?
MediHelp rates the interaction as moderate. Dipipanone and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dipipanone is an opioid analgesic that, with pimozide, can cause additive sedation, hypotension and respiratory depression.
How serious is the interaction between Dipipanone and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low opioid dose and monitor sedation and respiratory rate. Avoid alcohol and other CNS depressants.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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