Drug interactions
Divalproex + Olanzapine / samidorphan
Severity: Minor
Divalproex and Olanzapine / samidorphan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valproate may lower olanzapine plasma concentrations in some patients, potentially reducing antipsychotic effect. The combination is also used clinically, and additive weight gain and sedation can occur.
What this interaction means in plain words
Divalproex and Olanzapine / samidorphan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mechanism is not firmly established; valproate may modestly increase olanzapine clearance, possibly via glucuronidation.
What to do
Monitor clinical response and psychiatric symptoms, and adjust olanzapine dose if efficacy declines. Monitor weight and metabolic parameters.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Frequently asked questions
Can I take Divalproex with Olanzapine / samidorphan?
MediHelp rates the interaction as minor. Divalproex and Olanzapine / samidorphan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valproate may lower olanzapine plasma concentrations in some patients, potentially reducing antipsychotic effect. The combination is also used clinically, and additive weight gain and sedation can occur.
How serious is the interaction between Divalproex and Olanzapine / samidorphan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and psychiatric symptoms, and adjust olanzapine dose if efficacy declines. Monitor weight and metabolic parameters.
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