Drug interactions
Donepezil + Echothiophate iodide
Severity: Moderate
Donepezil and Echothiophate iodide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Echothiophate is an irreversible cholinesterase inhibitor used in the eye, and donepezil is a reversible one. Systemic absorption can add to cholinergic effects such as bradycardia, gastrointestinal upset and bronchospasm.
What this interaction means in plain words
Donepezil and Echothiophate iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive acetylcholinesterase inhibition.
What to do
Monitor for systemic cholinergic symptoms and heart rate. Consider an alternative glaucoma therapy if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Echothiophate iodide?
MediHelp rates the interaction as moderate. Donepezil and Echothiophate iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Echothiophate is an irreversible cholinesterase inhibitor used in the eye, and donepezil is a reversible one. Systemic absorption can add to cholinergic effects such as bradycardia, gastrointestinal upset and bronchospasm.
How serious is the interaction between Donepezil and Echothiophate iodide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for systemic cholinergic symptoms and heart rate. Consider an alternative glaucoma therapy if adverse effects occur.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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