Drug interactions
Donepezil + Encorafenib
Severity: Moderate
Donepezil and Encorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib can prolong the QT interval in a concentration-dependent manner. Donepezil has its own torsades risk, so the combination may increase the likelihood of an arrhythmia.
What this interaction means in plain words
Donepezil and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Encorafenib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check baseline ECG and electrolytes and monitor them during treatment. Reduce or withhold encorafenib if QTc becomes substantially prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Donepezil with Encorafenib?
MediHelp rates the interaction as moderate. Donepezil and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib can prolong the QT interval in a concentration-dependent manner. Donepezil has its own torsades risk, so the combination may increase the likelihood of an arrhythmia.
How serious is the interaction between Donepezil and Encorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and monitor them during treatment. Reduce or withhold encorafenib if QTc becomes substantially prolonged.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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