Drug interactions
Donepezil + Fosamprenavir
Severity: Minor
Donepezil and Fosamprenavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir, through its active metabolite amprenavir, inhibits CYP3A4, which contributes to donepezil metabolism. Donepezil exposure may rise modestly, potentially increasing cholinergic effects such as nausea, bradycardia or diarrhea.
What this interaction means in plain words
Donepezil and Fosamprenavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated donepezil metabolism by amprenavir.
What to do
No routine dose change is needed; monitor heart rate and gastrointestinal tolerance when starting or stopping fosamprenavir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Fosamprenavir?
MediHelp rates the interaction as minor. Donepezil and Fosamprenavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosamprenavir, through its active metabolite amprenavir, inhibits CYP3A4, which contributes to donepezil metabolism. Donepezil exposure may rise modestly, potentially increasing cholinergic effects such as nausea, bradycardia or diarrhea.
How serious is the interaction between Donepezil and Fosamprenavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor heart rate and gastrointestinal tolerance when starting or stopping fosamprenavir.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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