Drug interactions
Donepezil + Gemtuzumab
Severity: Moderate
Donepezil and Gemtuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemtuzumab ozogamicin has been associated with QT prolongation, and donepezil may add to this risk. Patients receiving chemotherapy often have electrolyte disturbances and vomiting that increase risk.
What this interaction means in plain words
Donepezil and Gemtuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation.
What to do
Obtain an ECG and electrolytes before and during treatment. Correct potassium and magnesium, and review other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Gemtuzumab?
MediHelp rates the interaction as moderate. Donepezil and Gemtuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemtuzumab ozogamicin has been associated with QT prolongation, and donepezil may add to this risk. Patients receiving chemotherapy often have electrolyte disturbances and vomiting that increase risk.
How serious is the interaction between Donepezil and Gemtuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and electrolytes before and during treatment. Correct potassium and magnesium, and review other QT-prolonging drugs.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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