Drug interactions
Donepezil + Henbane
Severity: Moderate
Donepezil and Henbane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains hyoscyamine and scopolamine, which block muscarinic receptors and oppose donepezil. This may reduce cognitive benefit and cause confusion, dry mouth and tachycardia.
What this interaction means in plain words
Donepezil and Henbane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antimuscarinic alkaloids antagonize the effect of cholinesterase inhibition.
What to do
Avoid henbane-containing products in patients taking donepezil. If used, monitor cognition and anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Henbane?
MediHelp rates the interaction as moderate. Donepezil and Henbane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains hyoscyamine and scopolamine, which block muscarinic receptors and oppose donepezil. This may reduce cognitive benefit and cause confusion, dry mouth and tachycardia.
How serious is the interaction between Donepezil and Henbane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid henbane-containing products in patients taking donepezil. If used, monitor cognition and anticholinergic effects.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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