Drug interactions
Donepezil + Indinavir
Severity: Minor
Donepezil and Indinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4, a pathway involved in donepezil clearance, so donepezil levels may rise. This may heighten cholinergic adverse effects such as bradycardia, nausea and vomiting.
What this interaction means in plain words
Donepezil and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated donepezil metabolism by indinavir.
What to do
No routine dose change; monitor heart rate and GI tolerance when starting indinavir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Indinavir?
MediHelp rates the interaction as minor. Donepezil and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indinavir inhibits CYP3A4, a pathway involved in donepezil clearance, so donepezil levels may rise. This may heighten cholinergic adverse effects such as bradycardia, nausea and vomiting.
How serious is the interaction between Donepezil and Indinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor heart rate and GI tolerance when starting indinavir.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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