Drug interactions
Donepezil + Levosalbutamol
Severity: Moderate
Donepezil and Levosalbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil can prolong the QT interval and cause bradycardia, and levosalbutamol may add arrhythmic risk through hypokalemia and tachycardia. Cholinesterase inhibition and beta-agonism also have partly opposing effects on heart rate.
What this interaction means in plain words
Donepezil and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Levosalbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia contributing.
What to do
Monitor heart rate and rhythm, and check potassium in patients with cardiac disease or other QT-prolonging drugs. Obtain an ECG if syncope or palpitations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Levosalbutamol?
MediHelp rates the interaction as moderate. Donepezil and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil can prolong the QT interval and cause bradycardia, and levosalbutamol may add arrhythmic risk through hypokalemia and tachycardia. Cholinesterase inhibition and beta-agonism also have partly opposing effects on heart rate.
How serious is the interaction between Donepezil and Levosalbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and rhythm, and check potassium in patients with cardiac disease or other QT-prolonging drugs. Obtain an ECG if syncope or palpitations occur.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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