Drug interactions
Donepezil + Lofepramine
Severity: Moderate
Donepezil and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with anticholinergic activity that opposes donepezil's effect. Cognitive benefit may be reduced, and the combined cardiac effects may matter in susceptible patients.
What this interaction means in plain words
Donepezil and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism by antimuscarinic activity of the tricyclic.
What to do
Where possible, choose an antidepressant with less anticholinergic activity, such as an SSRI. Monitor cognition and heart rate if the combination is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Lofepramine?
MediHelp rates the interaction as moderate. Donepezil and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with anticholinergic activity that opposes donepezil's effect. Cognitive benefit may be reduced, and the combined cardiac effects may matter in susceptible patients.
How serious is the interaction between Donepezil and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, choose an antidepressant with less anticholinergic activity, such as an SSRI. Monitor cognition and heart rate if the combination is used.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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