Drug interactions
Donepezil + Lumefantrine
Severity: Moderate
Donepezil and Lumefantrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine inhibits CYP2D6 and may modestly raise donepezil levels. Both drugs have QT-prolonging potential, so the combination may increase arrhythmia risk.
What this interaction means in plain words
Donepezil and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP2D6 inhibition plus additive QT prolongation.
What to do
Monitor ECG and electrolytes if the combination cannot be avoided. Watch for bradycardia and cholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Lumefantrine?
MediHelp rates the interaction as moderate. Donepezil and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine inhibits CYP2D6 and may modestly raise donepezil levels. Both drugs have QT-prolonging potential, so the combination may increase arrhythmia risk.
How serious is the interaction between Donepezil and Lumefantrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes if the combination cannot be avoided. Watch for bradycardia and cholinergic effects.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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