Drug interactions
Donepezil + Olodaterol inhaled
Severity: Moderate
Donepezil and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil can prolong the QT interval, and inhaled olodaterol, a beta2-agonist, may add to cardiac effects. The risk is higher with hypokalemia or other QT-prolonging drugs.
What this interaction means in plain words
Donepezil and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation with beta2-agonist-related hypokalemia.
What to do
Check potassium in patients at risk and consider an ECG if other QT-prolonging drugs are used. Use olodaterol at the labeled dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Donepezil and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil can prolong the QT interval, and inhaled olodaterol, a beta2-agonist, may add to cardiac effects. The risk is higher with hypokalemia or other QT-prolonging drugs.
How serious is the interaction between Donepezil and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium in patients at risk and consider an ECG if other QT-prolonging drugs are used. Use olodaterol at the labeled dose.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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