Drug interactions
Donepezil + Rapacuronium
Severity: Moderate
Donepezil and Rapacuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholinesterase inhibitors like donepezil may prolong succinylcholine-type blockade and may antagonize nondepolarizing neuromuscular blockers. Rapacuronium is a nondepolarizing agent and has been withdrawn from most markets, and response may be unpredictable.
What this interaction means in plain words
Donepezil and Rapacuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased acetylcholine at the neuromuscular junction opposes competitive nondepolarizing blockade.
What to do
Monitor neuromuscular function with a nerve stimulator and titrate the blocker to effect. Tell the anesthetist about donepezil use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Rapacuronium?
MediHelp rates the interaction as moderate. Donepezil and Rapacuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholinesterase inhibitors like donepezil may prolong succinylcholine-type blockade and may antagonize nondepolarizing neuromuscular blockers. Rapacuronium is a nondepolarizing agent and has been withdrawn from most markets, and response may be unpredictable.
How serious is the interaction between Donepezil and Rapacuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a nerve stimulator and titrate the blocker to effect. Tell the anesthetist about donepezil use.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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