Drug interactions
Donepezil + Romidepsin
Severity: Moderate
Donepezil and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin can cause QT changes and electrolyte disturbances, and donepezil may also prolong QT. Combined use increases the risk of ventricular arrhythmias.
What this interaction means in plain words
Donepezil and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation.
What to do
Monitor ECG, potassium and magnesium before and during romidepsin treatment, and correct deficits. Consider an alternative if QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Romidepsin?
MediHelp rates the interaction as moderate. Donepezil and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin can cause QT changes and electrolyte disturbances, and donepezil may also prolong QT. Combined use increases the risk of ventricular arrhythmias.
How serious is the interaction between Donepezil and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, potassium and magnesium before and during romidepsin treatment, and correct deficits. Consider an alternative if QTc becomes prolonged.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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