Drug interactions
Donepezil + Umeclidinium bromide / vilanterol inhaled
Severity: Minor
Donepezil and Umeclidinium bromide / vilanterol inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil carries a risk of QT prolongation and bradycardia. Vilanterol, a long-acting beta-agonist, can cause tachycardia, hypokalemia and QT effects at higher exposure. Umeclidinium is an inhaled antimuscarinic that may partly oppose donepezil's cholinergic effects, though systemic exposure is low.
What this interaction means in plain words
Donepezil and Umeclidinium bromide / vilanterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive QT effects and weak pharmacodynamic opposition of cholinergic activity, both limited by low systemic exposure from inhalation.
What to do
No routine change is needed at usual doses. Monitor heart rate and symptoms of palpitations, and check potassium in patients with other QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Donepezil and Umeclidinium bromide / vilanterol inhaled, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as minor. Donepezil and Umeclidinium bromide / vilanterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Donepezil carries a risk of QT prolongation and bradycardia. Vilanterol, a long-acting beta-agonist, can cause tachycardia, hypokalemia and QT effects at higher exposure. Umeclidinium is an inhaled antimuscarinic that may partly oppose donepezil's cholinergic effects, though systemic exposure is low.
How serious is the interaction between Donepezil and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed at usual doses. Monitor heart rate and symptoms of palpitations, and check potassium in patients with other QT risk factors.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
