Drug interactions
Dopexamine + Hydrochlorothiazide-olmesartan
Severity: Moderate
Dopexamine and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dopexamine is a catecholamine-like inotrope that can lower serum potassium through beta-2 stimulation, while the thiazide component also depletes potassium and olmesartan tends to raise it. The net effect on potassium is unpredictable. Dopexamine's vasodilating action may also add to the blood pressure lowering of the combination.
What this interaction means in plain words
Dopexamine and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing and additive effects on potassium handling (beta-2 mediated cellular uptake and thiazide kaliuresis versus ARB-related potassium retention) plus additive vasodilation.
What to do
Monitor serum potassium and blood pressure during dopexamine infusion in patients taking this combination. Correct electrolyte abnormalities promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Dopexamine with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Dopexamine and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dopexamine is a catecholamine-like inotrope that can lower serum potassium through beta-2 stimulation, while the thiazide component also depletes potassium and olmesartan tends to raise it. The net effect on potassium is unpredictable. Dopexamine's vasodilating action may also add to the blood pressure lowering of the combination.
How serious is the interaction between Dopexamine and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure during dopexamine infusion in patients taking this combination. Correct electrolyte abnormalities promptly.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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