Drug interactions
Doxazosin + Enalapril
Severity: Moderate
Doxazosin and Enalapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an alpha-blocker with an ACE inhibitor may cause an exaggerated hypotensive response, particularly after the first doses. Volume-depleted or elderly patients are most at risk.
What this interaction means in plain words
Doxazosin and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Enalapril belongs to Cardiovascular.
Why it happens
Additive vasodilation from alpha-1 blockade and reduced angiotensin II formation.
What to do
Introduce the second agent at a low dose, preferably at bedtime, and monitor blood pressure and orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Doxazosin with Enalapril?
MediHelp rates the interaction as moderate. Doxazosin and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an alpha-blocker with an ACE inhibitor may cause an exaggerated hypotensive response, particularly after the first doses. Volume-depleted or elderly patients are most at risk.
How serious is the interaction between Doxazosin and Enalapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Introduce the second agent at a low dose, preferably at bedtime, and monitor blood pressure and orthostatic symptoms.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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