Drug interactions
Doxazosin + Fenoprofen
Severity: Moderate
Doxazosin and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoprofen may attenuate the antihypertensive effect of doxazosin through sodium and fluid retention. Blood pressure may rise during sustained concurrent use.
What this interaction means in plain words
Doxazosin and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Fenoprofen belongs to Musculoskeletal.
Why it happens
Prostaglandin synthesis inhibition leads to sodium retention and vasoconstriction.
What to do
Monitor blood pressure and adjust doxazosin if control is lost; use the lowest effective NSAID dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Doxazosin with Fenoprofen?
MediHelp rates the interaction as moderate. Doxazosin and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoprofen may attenuate the antihypertensive effect of doxazosin through sodium and fluid retention. Blood pressure may rise during sustained concurrent use.
How serious is the interaction between Doxazosin and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust doxazosin if control is lost; use the lowest effective NSAID dose.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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