Drug interactions
Doxazosin + Ketorolac
Severity: Moderate
Doxazosin and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac, like other NSAIDs, can blunt the blood pressure lowering effect of doxazosin. This may reduce blood pressure control in patients treated for hypertension, particularly with sustained or high-dose NSAID use.
What this interaction means in plain words
Doxazosin and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Ketorolac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium and fluid retention and reduces vasodilation, opposing the antihypertensive action.
What to do
Monitor blood pressure when ketorolac is started or stopped and keep NSAID courses as short as possible. Adjust the antihypertensive regimen if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Doxazosin with Ketorolac?
MediHelp rates the interaction as moderate. Doxazosin and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac, like other NSAIDs, can blunt the blood pressure lowering effect of doxazosin. This may reduce blood pressure control in patients treated for hypertension, particularly with sustained or high-dose NSAID use.
How serious is the interaction between Doxazosin and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when ketorolac is started or stopped and keep NSAID courses as short as possible. Adjust the antihypertensive regimen if control is lost.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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