Drug interactions
Doxazosin + Nitroglycerin rectal
Severity: Moderate
Doxazosin and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal nitroglycerin is a vasodilator, and combined use with doxazosin may produce additive hypotension and dizziness. Patients may be at risk of syncope, particularly when standing.
What this interaction means in plain words
Doxazosin and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation from nitric oxide-mediated venous and arterial relaxation and alpha-1 adrenergic blockade.
What to do
Advise patients to sit during and after application and to rise slowly. Monitor blood pressure and reduce doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Doxazosin and Nitroglycerin rectal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Frequently asked questions
Can I take Doxazosin with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Doxazosin and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal nitroglycerin is a vasodilator, and combined use with doxazosin may produce additive hypotension and dizziness. Patients may be at risk of syncope, particularly when standing.
How serious is the interaction between Doxazosin and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to sit during and after application and to rise slowly. Monitor blood pressure and reduce doses if hypotension occurs.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
