Drug interactions
Doxazosin + Parecoxib
Severity: Moderate
Doxazosin and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is converted to valdecoxib, a COX-2 inhibitor, which can cause fluid retention and raise blood pressure, thereby opposing antihypertensive therapy. Short perioperative courses usually have limited effect.
What this interaction means in plain words
Doxazosin and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
COX-2 inhibition reduces renal prostaglandins, causing sodium and water retention.
What to do
Monitor blood pressure during parecoxib use and adjust doxazosin if needed. Keep the course as short as possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Frequently asked questions
Can I take Doxazosin with Parecoxib?
MediHelp rates the interaction as moderate. Doxazosin and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib is converted to valdecoxib, a COX-2 inhibitor, which can cause fluid retention and raise blood pressure, thereby opposing antihypertensive therapy. Short perioperative courses usually have limited effect.
How serious is the interaction between Doxazosin and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during parecoxib use and adjust doxazosin if needed. Keep the course as short as possible.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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