Drug interactions
Doxazosin + Pindolol
Severity: Moderate
Doxazosin and Pindolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an alpha-1 blocker with a beta-blocker adds to the blood pressure lowering effect. This can cause orthostatic hypotension and syncope, especially when doxazosin is started or the dose raised.
What this interaction means in plain words
Doxazosin and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic antihypertensive effect from alpha-1 blockade and beta-blockade.
What to do
Introduce doxazosin at a low dose and titrate gradually. Monitor orthostatic blood pressure and heart rate after each change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Frequently asked questions
Can I take Doxazosin with Pindolol?
MediHelp rates the interaction as moderate. Doxazosin and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an alpha-1 blocker with a beta-blocker adds to the blood pressure lowering effect. This can cause orthostatic hypotension and syncope, especially when doxazosin is started or the dose raised.
How serious is the interaction between Doxazosin and Pindolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Introduce doxazosin at a low dose and titrate gradually. Monitor orthostatic blood pressure and heart rate after each change.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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