Drug interactions
Doxazosin + Yohimbe
Severity: Moderate
Doxazosin and Yohimbe: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbe (yohimbine) blocks alpha-2 adrenoceptors and raises sympathetic outflow, which can oppose the antihypertensive and symptomatic effect of doxazosin. It may cause unpredictable blood pressure swings, tachycardia and anxiety.
What this interaction means in plain words
Doxazosin and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Yohimbine's alpha-2 antagonism increases noradrenaline release and pharmacologically opposes alpha-1 blockade, producing unpredictable hemodynamic effects.
What to do
Advise patients to avoid yohimbe supplements while taking doxazosin. If used, monitor blood pressure and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Frequently asked questions
Can I take Doxazosin with Yohimbe?
MediHelp rates the interaction as moderate. Doxazosin and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbe (yohimbine) blocks alpha-2 adrenoceptors and raises sympathetic outflow, which can oppose the antihypertensive and symptomatic effect of doxazosin. It may cause unpredictable blood pressure swings, tachycardia and anxiety.
How serious is the interaction between Doxazosin and Yohimbe?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid yohimbe supplements while taking doxazosin. If used, monitor blood pressure and heart rate.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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