Drug interactions
Doxorubicin + Fexinidazole
Severity: Moderate
Doxorubicin and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole inhibits CYP3A4 and may increase doxorubicin levels, raising the risk of myelosuppression and cardiotoxicity. Both drugs may also affect cardiac function or QT interval.
What this interaction means in plain words
Doxorubicin and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibits CYP3A4, possibly reducing doxorubicin metabolism.
What to do
Monitor blood counts, ECG and cardiac function during co-treatment. Consider reducing the doxorubicin dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Frequently asked questions
Can I take Doxorubicin with Fexinidazole?
MediHelp rates the interaction as moderate. Doxorubicin and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole inhibits CYP3A4 and may increase doxorubicin levels, raising the risk of myelosuppression and cardiotoxicity. Both drugs may also affect cardiac function or QT interval.
How serious is the interaction between Doxorubicin and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, ECG and cardiac function during co-treatment. Consider reducing the doxorubicin dose if toxicity appears.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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