Drug interactions
Doxorubicin + Glecaprevir / pibrentasvir
Severity: Moderate
Doxorubicin and Glecaprevir / pibrentasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-gp and BCRP and may raise doxorubicin exposure. Higher levels could worsen myelosuppression and cardiotoxicity.
What this interaction means in plain words
Doxorubicin and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of intestinal and hepatic P-gp and BCRP efflux transporters reduces doxorubicin clearance.
What to do
Monitor blood counts and signs of anthracycline toxicity; consider deferring hepatitis C therapy or reducing doxorubicin dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Frequently asked questions
Can I take Doxorubicin with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as moderate. Doxorubicin and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit P-gp and BCRP and may raise doxorubicin exposure. Higher levels could worsen myelosuppression and cardiotoxicity.
How serious is the interaction between Doxorubicin and Glecaprevir / pibrentasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of anthracycline toxicity; consider deferring hepatitis C therapy or reducing doxorubicin dose if toxicity develops.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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