Drug interactions
Doxorubicin + Influenza virus vaccine trivalent adjuvanted
Severity: Moderate
Doxorubicin and Influenza virus vaccine trivalent adjuvanted: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chemotherapy with doxorubicin can reduce antibody response to inactivated influenza vaccine. The vaccine is not live, so there is no replication risk, and vaccination is still recommended for patients on chemotherapy.
What this interaction means in plain words
Doxorubicin and Influenza virus vaccine trivalent adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic myelosuppression and immunosuppression attenuate the vaccine immune response.
What to do
Do not withhold vaccination; ideally vaccinate before chemotherapy cycle starts or between cycles when counts have recovered. Consider that protection may be reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Frequently asked questions
Can I take Doxorubicin with Influenza virus vaccine trivalent adjuvanted?
MediHelp rates the interaction as moderate. Doxorubicin and Influenza virus vaccine trivalent adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chemotherapy with doxorubicin can reduce antibody response to inactivated influenza vaccine. The vaccine is not live, so there is no replication risk, and vaccination is still recommended for patients on chemotherapy.
How serious is the interaction between Doxorubicin and Influenza virus vaccine trivalent adjuvanted?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not withhold vaccination; ideally vaccinate before chemotherapy cycle starts or between cycles when counts have recovered. Consider that protection may be reduced.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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