Drug interactions
Doxorubicin + Isoniazid
Severity: Minor
Doxorubicin and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxorubicin is partly metabolized by CYP3A4 and is a P-gp substrate, so isoniazid could theoretically increase its exposure. Evidence of a clinically important interaction is weak. Both drugs can add to liver stress.
What this interaction means in plain words
Doxorubicin and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxorubicin belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
Theoretical weak CYP3A4 inhibition by isoniazid reducing doxorubicin clearance.
What to do
Monitor liver function and blood counts as routinely done during chemotherapy. No dose adjustment is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Doxorubicin
Frequently asked questions
Can I take Doxorubicin with Isoniazid?
MediHelp rates the interaction as minor. Doxorubicin and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxorubicin is partly metabolized by CYP3A4 and is a P-gp substrate, so isoniazid could theoretically increase its exposure. Evidence of a clinically important interaction is weak. Both drugs can add to liver stress.
How serious is the interaction between Doxorubicin and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function and blood counts as routinely done during chemotherapy. No dose adjustment is usually needed.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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