Drug interactions
Doxorubicin + Nefazodone
Severity: Moderate
Doxorubicin and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a potent CYP3A4 inhibitor and may raise doxorubicin concentrations, increasing the risk of myelosuppression and cardiotoxicity.
What this interaction means in plain words
Doxorubicin and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nefazodone inhibits CYP3A4, reducing doxorubicin metabolism.
What to do
Consider switching to an antidepressant without CYP3A4 inhibition. If continued, monitor blood counts and cardiac function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Frequently asked questions
Can I take Doxorubicin with Nefazodone?
MediHelp rates the interaction as moderate. Doxorubicin and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone is a potent CYP3A4 inhibitor and may raise doxorubicin concentrations, increasing the risk of myelosuppression and cardiotoxicity.
How serious is the interaction between Doxorubicin and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider switching to an antidepressant without CYP3A4 inhibition. If continued, monitor blood counts and cardiac function.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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