Drug interactions
Doxorubicin + Olaparib
Severity: Major
Doxorubicin and Olaparib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining olaparib with a DNA-damaging myelosuppressive agent such as doxorubicin can worsen and prolong bone marrow suppression. Anemia, neutropenia and thrombocytopenia may be more severe.
What this interaction means in plain words
Doxorubicin and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Doxorubicin belongs to Oncology; Olaparib belongs to Oncology.
Why it happens
Additive myelosuppression from PARP inhibition and anthracycline-induced DNA damage.
What to do
Monitor complete blood counts frequently and reduce doses or delay treatment for significant cytopenias; only combine under oncology protocols.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Doxorubicin
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Doxorubicin with Olaparib?
MediHelp rates the interaction as major. Doxorubicin and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining olaparib with a DNA-damaging myelosuppressive agent such as doxorubicin can worsen and prolong bone marrow suppression. Anemia, neutropenia and thrombocytopenia may be more severe.
How serious is the interaction between Doxorubicin and Olaparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and reduce doses or delay treatment for significant cytopenias; only combine under oncology protocols.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
