Drug interactions
Doxorubicin + Paclitaxel protein bound
Severity: Moderate
Doxorubicin and Paclitaxel protein bound: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taxanes given with doxorubicin have been reported to reduce doxorubicin clearance and raise its levels, increasing the potential for cardiotoxicity and myelosuppression. The effect is best described for conventional paclitaxel and is extrapolated here.
What this interaction means in plain words
Doxorubicin and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Paclitaxel may reduce biliary and hepatic clearance of doxorubicin, possibly via transporter or metabolic competition.
What to do
Monitor cardiac function and blood counts, and track cumulative anthracycline dose. Consider sequencing doxorubicin before the taxane.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Frequently asked questions
Can I take Doxorubicin with Paclitaxel protein bound?
MediHelp rates the interaction as moderate. Doxorubicin and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taxanes given with doxorubicin have been reported to reduce doxorubicin clearance and raise its levels, increasing the potential for cardiotoxicity and myelosuppression. The effect is best described for conventional paclitaxel and is extrapolated here.
How serious is the interaction between Doxorubicin and Paclitaxel protein bound?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cardiac function and blood counts, and track cumulative anthracycline dose. Consider sequencing doxorubicin before the taxane.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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