Drug interactions
Doxorubicin + Sofosbuvir / velpatasvir
Severity: Moderate
Doxorubicin and Sofosbuvir / velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits BCRP and P-gp, and doxorubicin is a substrate of both transporters. Exposure to doxorubicin might therefore rise, increasing myelosuppression and cardiac toxicity. Clinical data are lacking.
What this interaction means in plain words
Doxorubicin and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Velpatasvir inhibits BCRP and P-gp transporters, decreasing doxorubicin efflux.
What to do
Monitor blood counts and cardiac status during combined use. Reduce the doxorubicin dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Frequently asked questions
Can I take Doxorubicin with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as moderate. Doxorubicin and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir inhibits BCRP and P-gp, and doxorubicin is a substrate of both transporters. Exposure to doxorubicin might therefore rise, increasing myelosuppression and cardiac toxicity. Clinical data are lacking.
How serious is the interaction between Doxorubicin and Sofosbuvir / velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac status during combined use. Reduce the doxorubicin dose if toxicity develops.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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