Drug interactions
Doxorubicin + Streptozocin
Severity: Moderate
Doxorubicin and Streptozocin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Streptozocin is nephrotoxic and can cause hepatic dysfunction, and doxorubicin is eliminated mainly through the liver. Labeling for the combination has described prolonged doxorubicin half-life, so toxicity may increase. The combination is used in neuroendocrine tumors with dose modification.
What this interaction means in plain words
Doxorubicin and Streptozocin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Streptozocin may reduce doxorubicin clearance, with the exact mechanism unestablished.
What to do
Consider reducing the doxorubicin dose and monitor liver tests, renal function, blood counts and cardiac function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Frequently asked questions
Can I take Doxorubicin with Streptozocin?
MediHelp rates the interaction as moderate. Doxorubicin and Streptozocin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Streptozocin is nephrotoxic and can cause hepatic dysfunction, and doxorubicin is eliminated mainly through the liver. Labeling for the combination has described prolonged doxorubicin half-life, so toxicity may increase. The combination is used in neuroendocrine tumors with dose modification.
How serious is the interaction between Doxorubicin and Streptozocin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the doxorubicin dose and monitor liver tests, renal function, blood counts and cardiac function.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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