Drug interactions
Doxorubicin + Tofacitinib
Severity: Major
Doxorubicin and Tofacitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxorubicin is myelosuppressive and immunosuppressive, and tofacitinib adds JAK-mediated immunosuppression. Together they can increase the risk of serious infections, including opportunistic infections, and of profound cytopenias.
What this interaction means in plain words
Doxorubicin and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Doxorubicin belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic immunosuppression and bone marrow suppression.
What to do
Avoid combining unless clearly necessary; tofacitinib labeling advises against use with potent immunosuppressants. If used together, monitor blood counts and infection signs closely and interrupt tofacitinib if serious infection or cytopenia develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Doxorubicin
Frequently asked questions
Can I take Doxorubicin with Tofacitinib?
MediHelp rates the interaction as major. Doxorubicin and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Doxorubicin is myelosuppressive and immunosuppressive, and tofacitinib adds JAK-mediated immunosuppression. Together they can increase the risk of serious infections, including opportunistic infections, and of profound cytopenias.
How serious is the interaction between Doxorubicin and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless clearly necessary; tofacitinib labeling advises against use with potent immunosuppressants. If used together, monitor blood counts and infection signs closely and interrupt tofacitinib if serious infection or cytopenia develops.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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