Drug interactions
Doxorubicin liposomal + Mercaptopurine
Severity: Moderate
Doxorubicin liposomal and Mercaptopurine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause myelosuppression and hepatotoxicity, so combined use may increase these toxicities. Infection risk rises when blood counts fall.
What this interaction means in plain words
Doxorubicin liposomal and Mercaptopurine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic bone marrow suppression and hepatic toxicity.
What to do
Monitor complete blood counts and liver function tests regularly. Reduce the dose of either agent for significant cytopenias or liver enzyme elevation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mercaptopurine
- Adenovirus types 4 and 7 live + Mercaptopurine Contraindicated
- Azathioprine + Mercaptopurine Contraindicated
- Bcg vaccine live + Mercaptopurine Contraindicated
- Febuxostat + Mercaptopurine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mercaptopurine Contraindicated
- Mercaptopurine + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Doxorubicin liposomal with Mercaptopurine?
MediHelp rates the interaction as moderate. Doxorubicin liposomal and Mercaptopurine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause myelosuppression and hepatotoxicity, so combined use may increase these toxicities. Infection risk rises when blood counts fall.
How serious is the interaction between Doxorubicin liposomal and Mercaptopurine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and liver function tests regularly. Reduce the dose of either agent for significant cytopenias or liver enzyme elevation.
What other medicines interact with Mercaptopurine?
MediHelp also lists interactions of Mercaptopurine with, for example, Adenovirus types 4 and 7 live, Azathioprine, Bcg vaccine live. The full list is on the Mercaptopurine page.
Full monographs, dosing and an interaction checker in the MediHelp app
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