Drug interactions
Droperidol + Pimozide
Severity: Contraindicated
Droperidol and Pimozide: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are potent QT-prolonging butyrophenone-type antipsychotics with documented torsades de pointes risk. Taken together, the risk of life-threatening arrhythmia is considerably increased.
What this interaction means in plain words
Droperidol and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive QT prolongation by hERG potassium channel blockade.
What to do
Do not combine. Use a non-QT-prolonging antiemetic or sedative in patients taking pimozide.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Droperidol with Pimozide?
MediHelp rates the interaction as contraindicated. Droperidol and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs are potent QT-prolonging butyrophenone-type antipsychotics with documented torsades de pointes risk. Taken together, the risk of life-threatening arrhythmia is considerably increased.
How serious is the interaction between Droperidol and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use a non-QT-prolonging antiemetic or sedative in patients taking pimozide.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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