Drug interactions
Droperidol + Ropinirole
Severity: Major
Droperidol and Ropinirole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol is a potent dopamine D2 antagonist, and ropinirole is a D2 agonist, so each reduces the other's effect. Droperidol may worsen parkinsonism and blunt ropinirole's benefit. Droperidol also prolongs the QT interval.
What this interaction means in plain words
Droperidol and Ropinirole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Avoid droperidol in patients with Parkinson disease and use an alternative antiemetic such as domperidone where available or ondansetron with ECG awareness. If needed, monitor motor function closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
- Loxapine + Ropinirole Major
Frequently asked questions
Can I take Droperidol with Ropinirole?
MediHelp rates the interaction as major. Droperidol and Ropinirole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Droperidol is a potent dopamine D2 antagonist, and ropinirole is a D2 agonist, so each reduces the other's effect. Droperidol may worsen parkinsonism and blunt ropinirole's benefit. Droperidol also prolongs the QT interval.
How serious is the interaction between Droperidol and Ropinirole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid droperidol in patients with Parkinson disease and use an alternative antiemetic such as domperidone where available or ondansetron with ECG awareness. If needed, monitor motor function closely.
What other medicines interact with Ropinirole?
MediHelp also lists interactions of Ropinirole with, for example, Amisulpride, Chlorpromazine, Fluphenazine. The full list is on the Ropinirole page.
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