Drug interactions
Elvitegravir + Ethinyl estradiol-levonorgestrel
Severity: Moderate
Elvitegravir and Ethinyl estradiol-levonorgestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elvitegravir, given with cobicistat, alters exposure to hormonal contraceptives: the combination increases progestin exposure and may decrease ethinyl estradiol exposure. The net effect on contraceptive reliability and hormone-related adverse effects is uncertain.
What this interaction means in plain words
Elvitegravir and Ethinyl estradiol-levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat-boosted regimens modulate CYP3A and other pathways; the mechanism for the estradiol decrease is not fully established.
What to do
Add or substitute a non-hormonal contraceptive method, or use an alternative such as an intrauterine device. Check the specific labeling for the antiretroviral regimen in use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elvitegravir with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as moderate. Elvitegravir and Ethinyl estradiol-levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elvitegravir, given with cobicistat, alters exposure to hormonal contraceptives: the combination increases progestin exposure and may decrease ethinyl estradiol exposure. The net effect on contraceptive reliability and hormone-related adverse effects is uncertain.
How serious is the interaction between Elvitegravir and Ethinyl estradiol-levonorgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Add or substitute a non-hormonal contraceptive method, or use an alternative such as an intrauterine device. Check the specific labeling for the antiretroviral regimen in use.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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