Drug interactions
Elvitegravir + Isoniazid
Severity: Minor
Elvitegravir and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elvitegravir is cleared mainly by CYP3A, but isoniazid is only a weak inhibitor. Any increase in elvitegravir exposure is expected to be small and of limited clinical importance.
What this interaction means in plain words
Elvitegravir and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by isoniazid may modestly reduce elvitegravir metabolism.
What to do
No dose change is needed. Routine monitoring of HIV therapy and tolerability is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Elvitegravir with Isoniazid?
MediHelp rates the interaction as minor. Elvitegravir and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elvitegravir is cleared mainly by CYP3A, but isoniazid is only a weak inhibitor. Any increase in elvitegravir exposure is expected to be small and of limited clinical importance.
How serious is the interaction between Elvitegravir and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Routine monitoring of HIV therapy and tolerability is sufficient.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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