Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Ethosuximide
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ethosuximide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP3A4, which contributes to ethosuximide metabolism, and may raise its levels. Higher concentrations may cause drowsiness, nausea and ataxia.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ethosuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP3A4, decreasing the oxidative metabolism of ethosuximide.
What to do
Monitor for ethosuximide toxicity and consider a dose reduction or serum concentration monitoring when starting or stopping cobicistat.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Ethosuximide?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ethosuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP3A4, which contributes to ethosuximide metabolism, and may raise its levels. Higher concentrations may cause drowsiness, nausea and ataxia.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ethosuximide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ethosuximide toxicity and consider a dose reduction or serum concentration monitoring when starting or stopping cobicistat.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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