Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Exemestane
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Exemestane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Exemestane is metabolized by CYP3A4, so cobicistat may raise its levels. Exemestane has a wide therapeutic margin, so the clinical effect is probably modest, with possible increased adverse effects such as hot flashes, arthralgia or fatigue.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Exemestane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP3A4, reducing exemestane metabolism.
What to do
Continue exemestane at the standard dose and monitor for increased adverse effects. Consider alternative therapy only if intolerance develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Exemestane
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Exemestane?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Exemestane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Exemestane is metabolized by CYP3A4, so cobicistat may raise its levels. Exemestane has a wide therapeutic margin, so the clinical effect is probably modest, with possible increased adverse effects such as hot flashes, arthralgia or fatigue.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Exemestane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue exemestane at the standard dose and monitor for increased adverse effects. Consider alternative therapy only if intolerance develops.
What other medicines interact with Exemestane?
MediHelp also lists interactions of Exemestane with, for example, Bazedoxifene-conjugated estrogens, Desogestrel-ethinyl estradiol, Estradiol. The full list is on the Exemestane page.
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