Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fenoprofen
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is eliminated by the kidney and is nephrotoxic, and NSAIDs can reduce renal perfusion. Concurrent use, particularly with high-dose or prolonged NSAID therapy, increases the risk of acute kidney injury and tenofovir-related tubular toxicity. Cobicistat also raises serum creatinine by blocking tubular secretion, which can mask changes.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from NSAID-mediated reduction in renal blood flow and tenofovir proximal tubular injury, with competition for renal elimination.
What to do
Prefer a non-NSAID analgesic such as acetaminophen. If an NSAID is necessary, use the lowest dose briefly and monitor renal function, including phosphate and urine protein.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fenoprofen, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Fenoprofen?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir is eliminated by the kidney and is nephrotoxic, and NSAIDs can reduce renal perfusion. Concurrent use, particularly with high-dose or prolonged NSAID therapy, increases the risk of acute kidney injury and tenofovir-related tubular toxicity. Cobicistat also raises serum creatinine by blocking tubular secretion, which can mask changes.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic such as acetaminophen. If an NSAID is necessary, use the lowest dose briefly and monitor renal function, including phosphate and urine protein.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
