Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lansoprazole
Severity: Minor
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP3A4, which contributes to lansoprazole metabolism, but studies with this combination and PPIs showed no clinically significant interaction. Elvitegravir absorption is not meaningfully affected by PPIs.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cobicistat inhibits CYP3A4, but the effect on lansoprazole has little clinical importance.
What to do
No dose adjustment is required; routine monitoring is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Lansoprazole?
MediHelp rates the interaction as minor. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cobicistat inhibits CYP3A4, which contributes to lansoprazole metabolism, but studies with this combination and PPIs showed no clinically significant interaction. Elvitegravir absorption is not meaningfully affected by PPIs.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; routine monitoring is sufficient.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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