Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Pimozide
Severity: Contraindicated
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Pimozide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat potently inhibits CYP3A4 and CYP2D6 and can markedly raise pimozide concentrations. This increases the risk of QT prolongation and torsades de pointes.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Cobicistat inhibits CYP3A4 and CYP2D6, decreasing pimozide metabolism.
What to do
Do not co-administer. Use an alternative antipsychotic or antiretroviral regimen without a booster.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Pimozide?
MediHelp rates the interaction as contraindicated. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat potently inhibits CYP3A4 and CYP2D6 and can markedly raise pimozide concentrations. This increases the risk of QT prolongation and torsades de pointes.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Use an alternative antipsychotic or antiretroviral regimen without a booster.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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