Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Raltegravir
Severity: Contraindicated
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Raltegravir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The elvitegravir-containing product is a complete single-tablet regimen, and adding raltegravir duplicates integrase inhibitor therapy with no established benefit. Safety and efficacy of this combination have not been studied.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Raltegravir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Therapeutic duplication of two integrase strand transfer inhibitors; no established pharmacokinetic mechanism.
What to do
Do not combine; use the complete regimen alone or build a regimen with raltegravir and other appropriate agents.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Raltegravir
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Raltegravir?
MediHelp rates the interaction as contraindicated. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Raltegravir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The elvitegravir-containing product is a complete single-tablet regimen, and adding raltegravir duplicates integrase inhibitor therapy with no established benefit. Safety and efficacy of this combination have not been studied.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Raltegravir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use the complete regimen alone or build a regimen with raltegravir and other appropriate agents.
What other medicines interact with Raltegravir?
MediHelp also lists interactions of Raltegravir with, for example, Aluminum hydroxide / magnesium carbonate, Aluminum hydroxide / magnesium trisilicate, Aluminum hydroxide. The full list is on the Raltegravir page.
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