Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Rifaximin
Severity: Minor
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Rifaximin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits P-glycoprotein and may raise systemic rifaximin levels. The effect is probably small in most patients because rifaximin is poorly absorbed.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Rifaximin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cobicistat inhibition of P-glycoprotein reducing rifaximin efflux.
What to do
No dose adjustment is routinely needed. Monitor patients with severe hepatic impairment for rifaximin adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rifaximin
- Cholera vaccine + Rifaximin Major
- Microbiota + Rifaximin Major
- Amiodarone + Rifaximin Moderate
- Bcg intravesical live + Rifaximin Moderate
- Cyclosporine + Rifaximin Moderate
- Cyclosporin + Rifaximin Moderate
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Rifaximin?
MediHelp rates the interaction as minor. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Rifaximin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cobicistat inhibits P-glycoprotein and may raise systemic rifaximin levels. The effect is probably small in most patients because rifaximin is poorly absorbed.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Rifaximin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely needed. Monitor patients with severe hepatic impairment for rifaximin adverse effects.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
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