Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Tenofovir disoproxil
Severity: Contraindicated
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Tenofovir disoproxil: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The fixed-dose combination already contains tenofovir disoproxil fumarate, so adding separate tenofovir duplicates therapy. This leads to excess tenofovir exposure and raises the risk of renal and bone toxicity without added benefit.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Tenofovir disoproxil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Therapeutic duplication of tenofovir DF, leading to additive exposure and nephrotoxicity.
What to do
Do not co-administer; use the single-tablet regimen alone and do not add other antiretrovirals or additional tenofovir products.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Tenofovir disoproxil?
MediHelp rates the interaction as contraindicated. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Tenofovir disoproxil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The fixed-dose combination already contains tenofovir disoproxil fumarate, so adding separate tenofovir duplicates therapy. This leads to excess tenofovir exposure and raises the risk of renal and bone toxicity without added benefit.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Tenofovir disoproxil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use the single-tablet regimen alone and do not add other antiretrovirals or additional tenofovir products.
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