Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Venlafaxine
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP2D6 and CYP3A4, the main routes of venlafaxine metabolism, so venlafaxine exposure may rise. This can increase nausea, hypertension, tachycardia, and the risk of serotonin toxicity.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP2D6 and CYP3A4, decreasing clearance of venlafaxine.
What to do
Use the lowest effective venlafaxine dose and titrate slowly. Monitor blood pressure, heart rate, and signs of serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Venlafaxine?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP2D6 and CYP3A4, the main routes of venlafaxine metabolism, so venlafaxine exposure may rise. This can increase nausea, hypertension, tachycardia, and the risk of serotonin toxicity.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective venlafaxine dose and titrate slowly. Monitor blood pressure, heart rate, and signs of serotonin toxicity.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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