Drug interactions
Empagliflozin-linagliptin + Hydrocortisone
Severity: Moderate
Empagliflozin-linagliptin and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic hydrocortisone can raise blood glucose and oppose the effect of antidiabetic drugs, so glycemic control may worsen. It is not a clinically meaningful CYP3A4 inducer for linagliptin.
What this interaction means in plain words
Empagliflozin-linagliptin and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-linagliptin belongs to Endocrine; Hydrocortisone belongs to Endocrine.
Why it happens
Glucocorticoid-induced insulin resistance and increased hepatic glucose output oppose the antihyperglycemic effect.
What to do
Monitor blood glucose during systemic corticosteroid therapy and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Empagliflozin-linagliptin with Hydrocortisone?
MediHelp rates the interaction as moderate. Empagliflozin-linagliptin and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic hydrocortisone can raise blood glucose and oppose the effect of antidiabetic drugs, so glycemic control may worsen. It is not a clinically meaningful CYP3A4 inducer for linagliptin.
How serious is the interaction between Empagliflozin-linagliptin and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during systemic corticosteroid therapy and adjust antidiabetic therapy as needed.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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