Drug interactions
Empagliflozin-linagliptin + Indapamide
Severity: Moderate
Empagliflozin-linagliptin and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin causes osmotic diuresis and natriuresis, and indapamide is a thiazide-like diuretic, so the two together can produce greater fluid and sodium loss. This may lead to volume depletion, hypotension, dizziness, electrolyte disturbance and a rise in creatinine, particularly in older or frail patients.
What this interaction means in plain words
Empagliflozin-linagliptin and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-linagliptin belongs to Endocrine; Indapamide belongs to Cardiovascular.
Why it happens
Additive diuretic and natriuretic effects of the SGLT2 inhibitor and the thiazide-like diuretic.
What to do
Assess volume status, blood pressure, renal function and electrolytes after starting or changing either drug. Consider reducing the diuretic dose in patients at risk of volume depletion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Indapamide
Frequently asked questions
Can I take Empagliflozin-linagliptin with Indapamide?
MediHelp rates the interaction as moderate. Empagliflozin-linagliptin and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin causes osmotic diuresis and natriuresis, and indapamide is a thiazide-like diuretic, so the two together can produce greater fluid and sodium loss. This may lead to volume depletion, hypotension, dizziness, electrolyte disturbance and a rise in creatinine, particularly in older or frail patients.
How serious is the interaction between Empagliflozin-linagliptin and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status, blood pressure, renal function and electrolytes after starting or changing either drug. Consider reducing the diuretic dose in patients at risk of volume depletion.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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